12 Jun 2012 Fondaparinux · Trade Name: Arixtra ® · Drug Class: Factor Xa inhibitor · Mechanism of Action: Avidly binds antithrombin with high specificity,

Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period.

The manufacturer suggests that if platelet counts fall below 100,000 mm3, fondaparinux should be discontinued. INTRODUCTION Fondaparinux (Arixtra) is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin (AT) binding region of heparin. Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all. Consider 1) holding fondaparinux until bleeding resolves; 2) reduction in dosing; and/or 3) increase in dosing interval: Serious or life threatening bleeding: Requires inpatient admission Follow UW Medicine guidelines for reversal of anticoagulation and management of bleeding The molecular formula of fondaparinux sodium is C 31 H 43 N 3 Na 10 O 49 S 8 and its molecular weight is 1728. The structural formula is provided below: ARIXTRA is supplied as a sterile, preservative-free injectable solution for subcutaneous use.

Böjningar av Fondaparinux neutrum Fondaparinux je syntetický a selektivní inhibitor aktivovaného faktoru X (Xa). Antitrombotická aktivita fondaparinuxu je výsledkem antitrombinem III (ATIII) zprostředkované selektivní inhibice faktoru Xa. Selektivní vazbou na ATIII fondaparinux zesiluje (asi 300x) přirozenou neutralizaci faktoru Xa ATIII. Fondaparinux, a direct selective inhibitor of factor Xa, overcomes many of the aforementioned disadvantages of low-molecular-weight heparins (LMWHs). Pharmacokinetic studies of fondaparinux reveal Fondaparinux adalah obat untuk mencegah dan mengobati penggumpalan darah pada vena dalam atau deep vein thrombosis (DVT). Untuk meningkatkan efektivitas pengobatan, fondaparinux biasanya dikombinasikan dengan warfarin. Fondaparinux bloquea la actividad de ciertas sustancias de la coagulación en la sangre.

Fondaparinux (molecular weight 1.728 kDa.) is a selective and reversible inhibitor of factor Xa dependent on binding to AT to elicit its activity. The K d of fondaparinux for AT is 48 ± 11 nM (139). Fondaparinux only promotes small increases in the HC II mediated antithrombin activity at high concentration (140).

2013-09-12

Significantly higher levels of anti-FXa activity were needed of fondaparinux efficacy compared with UFH. Fondaparinux Sodium is the sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity.Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. 👉👉 My NUMBER 1 Recommended Pharmacology Book - https://amzn.to/34R0Rts👉 Top 10 Pharmacology Book List - https://amzn.to/2Y8bqno👉 Best Medical Flash Cards Fondaparinux (Arixtra®) Major Bleeding Reversal - Protamine ineffective – Kcentra (4-factor PCC) 50 units/kg may be of use Dabigatran (Pradaxa®) Reverse if patient shows signs of intracranial hemorrhage 1. Idarucizumab 5 grams (two 2.5g vials) Xa Inhibitors Apixaban (Eliquis) ® Reverse if patient shows signs of life threatening bleeding 1.

A single fondaparinux molecule is recycled and re-binds to several consecutive ATIII molecules. The structurally changed ATIII-Xa complex is then cleared from circulation. The anti-Xa activity of fondaparinux reaches a maximum value in roughly 3 hours. Fondaparinux does not inactivate thrombin (factor IIa) and has no known effect on platelet function.

MAREVAN is a synthetic 4-hydroxycoumarin MOA: Base specific glycoylase removes altered base and creates AP site MOA: Binds to antithrombin to inhibit to factor Xa. 23. Fondaparinux MOA. Results showed that, like fondaparinux, rivaroxaban produced a concentration- dependent inhibition of clot-bound factor Xa. The IC50 for rivaroxaban was 75 nM •MOA: selectively inhibits active binding site for factor Xa on the coagulation cascade. •Side Effects: hemorrhage, anemia, thrombocytopenia. 29. 29. Arixtra® _____/_____ Fondaparinux (B) 2.5 mg SC once daily (avoid if CrCl <30 mL/min).

Tell your doctor if you have any bleeding or bruising while taking fondaparinux. Direct factor Xa inhibitors are able to block the action of both forms of factor Xa, whereas indirect factor Xa inhibitors such as heparin and fondaparinux (the antithrombin-binding pentasaccharide) are only able to inactivate factor Xa in the fluid phase, via antithrombin.
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Grade 1C- Strong recommendation, low or very-low quality of evidence Indications Although these agents are commonly used in similar populations, differences in their approved and off-label indications do exist. Indications UFH LMWH Fondaparinux Enoxaparin Frag 2013-09-12 Heparin MOA Complex with Anti-thrombin (AT) and inhibits factors Xa and IIA. Monitored by APTT (2-2.5 baseline therapeutic) 2 Heparin Route of Administration Mainly intravenous and also given subcutaneous 3 Comparison of Agents Argatroban Bivalirudin Danaparoid Fondaparinux MoA Direct thrombin inhibitor; Synthetic Direct thrombin inhibitor; Hirudin analogue Factor Xa inhibitor Factor Xa inhibitor; Synthetic analog of Antithrombin-binding pentasaccharide Clearance Hepatobiliary Enzymatic and renal Renal Renal Half-Life 40-50 min 25 min 24 hr 17-20 hr Dosing 2ug/kg/min IV infusion 0.15-2mg/kg/h IV Furthermore, fondaparinux has no reversal agent (unlike LMWH, which can be ~50% reversed with protamine). Fondaparinux has the advantage of never causing HIT, so: Fondaparinux can be used in a patient with a history of HIT. Fondaparinux use simplifies the workup for new-onset thrombocytopenia (you don't need to worry about HIT). FONDAPARINUX is used after knee, hip, or abdominal surgeries to prevent blood clotting.

heparinderivat (fondaparinux etc.) Fondaparinux (trade name Arixtra) is an anticoagulant medication chemically related to low molecular weight heparins. It is marketed by GlaxoSmithKline.
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Fondaparinux: MOA. Binds to antithrombin III and selectively enhances the inactivation of factor Xa. Fondaparinux: Contraindications. Active bleeding, bacterial

At the recommended dose, Fondaparinux does not affect fibrinolytic activity or bleeding time. Fondaparinux is a selective factor Xa inhibitor that binds reversibly to AT to produce an irreversible conformational change at the reactive site of AT that enhances its reactivity with factor Xa. 411 Once released from AT, fondaparinux is available to activate additional AT molecules, and it has been shown to have 100% bioavailability after SC injection with rapid absorption, achieving a steady state after three … Fondaparinux Kemiskt namn: Metyl-O-2-deoxi-6-O-sulfo-2- (sulfoamino)-α-D-glukopyranosyl-(1-4)-O-β-D- glukopyranuronosyl(1-4)-O-2-deoxi-3,6-di-O-sulfo-2- (sulfoamino)-α-D-glukopyranosyl-(1-4)-O-2-O-sulfo-α- L-idopyranuronosyl-(1-4)-2-deoxy-2-(sulfoamino)-, 6- (vätesulfat), dekanatriumsalt Fondaparinux is a synthetic pentasaccharide belonging to a new group of anticoagulants that inhibit thrombin formation by inhibiting Factor Xa, which is located at the crossing of both the intrinsic and extrinsic pathways. It has a favorable pharmacokinetic profile, and its effect is predictable and … Long Term Monitoring Guidelines FOR FONDAPARINUX; Patient weight: q1-3 months and adjust fondaparinux dose if needed: Platelet count: q1-3 months and PRN if bleeding is suspected or confirmed, or if thrombocytopenia is suspected or confirmed, and hold dosing as needed) Hematocrit Fondaparinux (Arixtra) is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin (AT) binding region of heparin. Similar to low molecular weight heparins, it is an indirect inhibitor of factor Xa, but it does not inhibit thrombin at all.

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Fondaparinux (molecular weight 1.728 kDa.) is a selective and reversible inhibitor of factor Xa dependent on binding to AT to elicit its activity. The K d of fondaparinux for AT is 48 ± 11 nM (139). Fondaparinux only promotes small increases in the HC II mediated antithrombin activity at high concentration (140).

It may supplant warfarin (Coumadin) in a number of applications as it may produce a more predictable, potent, and immediate anticoagulant effect, with fewer significant side effects and interactions, and requires less monitoring. Fondaparinux (trade name Arixtra) is an anticoagulant medication chemically related to low molecular weight heparins.

o Fondaparinux 0% · Indirectly restores activity of antifactors IIa, Xa (also VIIa/TF, IXa, XIa) Haemostatic side effects · Inconsistent reversal of Xa inhibition. o Doesn’t neutralize low MW heparins present in UFH · Re-heparinisation. o Shorter half life than heparin · Anticoagulation if excessive. o Interactions with platelets, fibrinogen

The hirudins can be used in patients with HIT c. Dabigatran is an oral thrombin inhibitor requiring twice daily dosing Introduction Coagulation is the process that is designed to prevent blood loss in the event of vascular injury. The A single fondaparinux molecule is recycled and re-binds to several consecutive ATIII molecules. The structurally changed ATIII-Xa complex is then cleared from circulation. The anti-Xa activity of fondaparinux reaches a maximum value in roughly 3 hours. Fondaparinux does not inactivate thrombin (factor IIa) and has no known effect on platelet function. III-mediated inhibition of factor Xa. Fondaparinux was 2-4 to 30 fold less potent than heparin on a weight basis, depending on the model used.

Fondaparinux Accession Number DB00569 Description.